Studies On Bovine Colostrum And Its Bioactive Nutrients* (1-8)

1. Arslan A, Kaplan M, Duman H, Bayraktar A, Ertürk M, Henrick BM, Frese SA, Karav S. Bovine Colostrum and Its Potential for Human Health and Nutrition. Front Nutr. 2021 Jun 21;8:651721. doi: 10.3389/fnut.2021.651721. PMID: 34235166; PMCID: PMC8255475.

2. Poonia A, Shiva. Bioactive compounds, nutritional profile and health benefits of colostrum: a review. Food Prod Process and Nutr. 2022;4(1):26. doi: 10.1186/s43014-022-00104-1. Epub 2022 Oct 25. PMCID: PMC9592540.

3. Muhammad Umar, Uracha Ruktanonchai, Davids Makararpong & Anil Kumar Anal (2023) Enhancing Immunity Against [patho-] Through Glycosylated Bovine Colostrum Proteins, Food Reviews International, DOI: 10.1080/87559129.2023.2169866

4. Artym J, Zimecki M. Colostrum and Lactoferrin Protect against Side Effects of Therapy with [Abx]...and Psychophysical Stress: A Comprehensive Review. Biomedicines. 2023 Mar 27;11(4):1015. doi: 10.3390/biomedicines11041015. PMID: 37189633; PMCID: PMC10136316.

5. Artym J, Zimecki M. Colostrum Proteins in Protection against Therapy-Induced Injuries in [CA]Chemo- and Radiotherapy: A Comprehensive Review. Biomedicines. 2023 Jan 3;11(1):114. doi: 10.3390/biomedicines11010114. PMID: 36672622; PMCID: PMC9856106.

6. Mach, J.-P. & Pahud, J.-J. (1971) Secretory IgA, a major immunoglobulin in most bovineexternal secretions. J. Immunol.106:552–563.

7. Hurley WL, Theil PK. Perspectives on immunoglobulins in colostrum and milk. Nutrients. 2011 Apr;3(4):442-74. doi: 10.3390/nu3040442. Epub 2011 Apr 14. PMID: 22254105; PMCID: PMC3257684.

8. Kowalczyk P, Kaczyńska K, Kleczkowska P, Bukowska-Ośko I, Kramkowski K, Sulejczak D. The Lactoferrin Phenomenon-A Miracle Molecule. Molecules. 2022 May 4;27(9):2941. doi: 10.3390/molecules27092941. PMID: 35566292; PMCID: PMC9104648.

Studies On The Importance Of Immune Barrier Function In Health* (1-10)

1. Liang L, Saunders C, Sanossian N. Food, gut barrier dysfunction, and related [dis-]: A new target for future individualized [dis-] prevention and management. Food Sci Nutr. 2023 Mar 7;11(4):1671-1704. doi: 10.1002/fsn3.3229. PMID: 37051344; PMCID: PMC10084985.
2. Bischoff, Stephan C et al. “Intestinal permeability--a new target for [dis-] prevention and therapy.” BMC gastroenterology vol. 14 189. 18 Nov. 2014.
3. Chelakkot et al, “Mechanisms regulating intestinal barrier integrity and its pathological implications.” Experimental & Molecular Medicine 50, Article number: 103 (2018).
4. Paray BA, Albeshr MF, Jan AT, Rather IA. [LG] and [Auto-immu-]: An Intricate Balance in Individuals Health and the [Dis-] State. Int J Mol Sci. 2020 Dec 21;21(24):9770. doi: 10.3390/ijms21249770. PMID: 33371435; PMCID: PMC7767453.
5. Graziani C, Laterza L, et al. Intestinal Permeability and Dysbiosis in Female Patients with Recurrent [Cysti-]: A Pilot Study. J Pers Med. 2022 Jun 20;12(6):1005. doi: 10.3390/jpm12061005. PMID: 35743789; PMCID: PMC9225239.
6. Niewiem M, Grzybowska-Chlebowczyk U. Intestinal Barrier Permeability in Allergic [Dis-]. Nutrients. 2022 Apr 30;14(9):1893. doi: 10.3390/nu14091893. PMID: 35565858; PMCID: PMC9101724.
7. Puricelli C, Rolla R, Gigliotti L, Boggio E, Beltrami E, Dianzani U, Keller R. The Gut-Brain-Immune Axis in [Aut-] Spectrum Disorders: A State-of-Art Report. Front Psychiatry. 2022 Feb 3;12:755171. doi: 10.3389/fpsyt.2021.755171. PMID: 35185631; PMCID: PMC8850385.
8. Wang LJ, Li SC, Yeh YM, Lee SY, Kuo HC, Yang CY. Gut mycobiome dysbiosis and its impact on intestinal permeability in attention-deficit/hyperactivity disorder. J Child Psychol Psychiatry. 2023 Sep;64(9):1280-1291. doi: 10.1111/jcpp.13779. Epub 2023 Apr 5. PMID: 37016804.
9. Hansson E, Skiöldebrand E. Low-grade [inflam-] causes gap junction-coupled cell dysfunction throughout the body, which can lead to the spread of systemic [inflam-]. Scand J Pain. 2019 Jun 28;19(4):639-649. doi: 10.1515/sjpain-2019-0061. PMID: 31251727.
10. Yazici D, Cagan E, Tan G, Li M, Do E, Kucukkase OC, Simsek A, Kizmaz MA, Bozkurt T, Aydin T, Heider A, Rückert B, Brüggen MC, Dhir R, O'Mahony L, Akdis M, Nadeau KC, Budak F, Akdis CA, Ogulur I. Disrupted epithelial permeability as a predictor of severe [Cov-] development. Allergy. 2023 Oct;78(10):2644-2658. doi: 10.1111/all.15800. Epub 2023 Jul 8. PMID: 37422701.

Studies Examining Bovine Colostrum's Impact On The Upper Respiratory System* (1-9)

1. Cesarone, Maria Rosaria, et al. “Prevention of [Infl-] Episodes With Colostrum Compared With Vaccination in Healthy and High-Risk Cardiovascular Subjects: The Epidemiologic Study in San Valentino.” Clinical and Applied Thrombosis/Hemostasis, Apr. 2007, pp. 130–136. PMID: 17456621.
2. Belcaro G, Cesarone MR, Cornelli U, Pellegini L, Ledda A, Grossi MG, Dugall M, Ruffini I, Fano F, Ricci A, Stuard S, Luzzi R, Grossi MG, Hosoi M. Prevention of [infl-] episodes with colostrum and Bifivir compared with vaccination: an epidemiological, registry study. Panminerva Med. 2010 Dec;52(4):269-75.
3. Alyne Batista da Silva Galdino, Adriano Henrique do Nascimento Rangel, Harpal Singh Buttar, Manuela Sales Lima Nascimento, Elaine Cristina Gavioli, Riva de Paula Oliveira, Danielle Cavalcanti Sales, Stela Antas Urbano & Katya Anaya (2021) Bovine colostrum: benefits for the human respiratory system and potential contributions for clinical management of [Cov-], Food and Agricultural Immunology, 32:1, 143-162, DOI: 10.1080/09540105.2021.1892594.
4. Swati Khartode S, Early Recovery of [Cov-] Patients by Using Immunoglobulins Present in Cow Colostrum Food Supplement - A Clinical Study, J Res Med Dent Sci, 2021, 9 (3):186-198.
5. Baśkiewicz-Hałasa M, Stachowska E, Grochans E, Maciejewska-Markiewicz D, Bühner L, Skonieczna-Żydecka K, Hałasa M. Moderate Dose Bovine Colostrum Supplementation in Prevention of Upper Respiratory Tract [Inf-] in Medical University Students: A Randomized, Triple Blind, Placebo-Controlled Trial. Nutrients. 2023; 15(8):1925. https://doi.org/10.3390/nu15081925
6. Hałasa M., Baśkiewicz-Hałasa M., Jamioł-Milc D., Maciejewska-Markiewicz D., Skonieczna-Żydecka K. Bovine colostrum supplementation in prevention of upper respiratory tract infec[Inf-]—Systematic review, meta-analysis and meta-regression of randomized controlled trials. J. Funct. Foods. 2022;99:105316. doi: 10.1016/j.jff.2022.105316.
7. Hałasa M, Skonieczna-Żydecka K, Machaliński B, Bühner L, Baśkiewicz-Hałasa M. Six Weeks of Supplementation with Bovine Colostrum Effectively Reduces URTIs Symptoms Frequency and Gravity for Up to 20 Weeks in Pre-School Children. Nutrients. 2023 Aug 18;15(16):3626. doi: 10.3390/nu15163626. PMID: 37630816; PMCID: PMC10459079.
8. Batista da Silva Galdino A, do Nascimento Rangel AH, Buttar HS, et al. Bovine colostrum: Benefits for the human respiratory system and potential contributions for clinical management of [Cov-]. Food and Agricultural Immunology. 2021;32(1):143-162. doi:10.1080/09540105.2021.1892594
9. Duman H, Karav S. Bovine colostrum and its potential contributions for treatment and prevention of [Cov-].Frontiers in Immunology. 2023;14. doi:https://www.frontiersin.org/articles/10.3389/fimmu.2023.1214514

Studies On Bovine Colostrum In Sports Performance, Recovery, And Body Composition* (1-11)

1. Antonio, J et al. “The effects of bovine colostrum supplementation on body composition and exercise performance in active men and women.” Nutrition (Burbank, Los Angeles County, Calif.) vol. 17,3 (2001): 243-7. doi:10.1016/s0899-9007(00)00552-9.
2. Davison, Glen. “Bovine colostrum and immune function after exercise.” Medicine and sport science vol. 59 (2012): 62-69. doi:10.1159/000341966
3. Główka, Natalia, and Małgorzata Woźniewicz. “Potential use of Colostrum Bovinum supplementation in athletes - A review.” Acta scientiarum polonorum. Technologia alimentaria vol. 18,2 (2019): 115-123. doi:10.17306/J.AFS.0654.
4. Shing, C.M., Hunter, D.C. & Stevenson, L.M. Bovine Colostrum Supplementation and Exercise Performance. Sports Med 39, 1033–1054 (2009). https://doi.org/10.2165/11317860-000000000-00000
5. Shing CM, Peake JM, Suzuki K, Jenkins DG, Coombes JS. A pilot study: bovine colostrum supplementation and hormonal and autonomic responses to competitive cycling. J Sports Med Phys Fitness. 2013 Oct;53(5):490-501. https://www.journalofdairyscience.org/article/S0022-0302(12)00343-8/fulltext.
6. Kotsis Y, Mikellidi A, Aresti C, Persia E, Sotiropoulos A, Panagiotakos DB, Antonopoulou S, Nomikos T. A low-dose, 6-week bovine colostrum supplementation maintains performance and attenuates [inflam-] indices following a Loughborough Intermittent Shuttle Test in soccer players. Eur J Nutr. 2018 Apr;57(3):1181-1195. doi: 10.1007/s00394-017-1401-7. Epub 2017 Mar 11. PMID: 28285432; PMCID: PMC5861165.
7. Crooks, C. V., Wall, C. R., Cross, M. L., & Rutherfurd-Markwick, K. J. (2006). The Effect of Bovine Colostrum Supplementation on Salivary IgA in Distance Runners, International Journal of Sport Nutrition and Exercise Metabolism, 16(1), 47-64.
8. Dziewiecka H, Buttar HS, Kasperska A, Ostapiuk-Karolczuk J, Domagalska M, Cichoń J, Skarpańska-Stejnborn A. A Systematic Review of the Influence of Bovine Colostrum Supplementation on [LGS] in Athletes: Diagnostic Biomarkers and Future Directions. Nutrients. 2022 Jun 17;14(12):2512. doi: 10.3390/nu14122512. PMID: 35745242; PMCID: PMC9227274.
9. Antonio J, Sanders MS, Van Gammeren D. The effects of bovine colostrum supplementation on body composition and exercise performance in active men and women. Nutrition. 2001 Mar;17(3):243-7. doi: 10.1016/s0899-9007(00)00552-9. PMID: 11312068.
10. Davison G. The Use of Bovine Colostrum in Sport and Exercise. Nutrients. 2021 May 24;13(6):1789. doi: 10.3390/nu13061789. PMID: 34073917; PMCID: PMC8225123.
11. Shing CM, Peake JM, Suzuki K, Jenkins DG, Coombes JS. A pilot study: bovine colostrum supplementation and hormonal and autonomic responses to competitive cycling. J Sports Med Phys Fitness. 2013 Oct;53(5):490-501. PMID: 23903529.

Studies on Bovine Colostrum, Metabolism, And Blood Glucose* (1-2)

1. Kim JH, Jung WS, Choi NJ, Kim DO, Shin DH, Kim YJ. Health-promoting effects of bovine colostrum in [T2D] patients can reduce blood glucose, cholesterol, triglyceride and ketones. J Nutr Biochem. 2009;20(4):298-303. doi:10.1016/j.jnutbio.2008.04.002
2. Ooi TC, Ahmad A, Rajab NF, Sharif R. The Effects of 12 Weeks Colostrum Milk Supplementation on the Expression Levels of Pro-[Infl-] Mediators and Metabolic Changes among Older Adults: Findings from the Biomarkers and Untargeted Metabolomic Analysis. Nutrients. 2023 Jul 18;15(14):3184. doi: 10.3390/nu15143184. PMID: 37513601; PMCID: PMC10384749.

Studies On Bovine Colostrum, Skin Health, And Hair Growth* (1-8)

1. Kazimierska K, Kalinowska-Lis U. Milk Proteins-Their Biological Activities and Use in Cosmetics and Dermatology. Molecules. 2021 May 28;26(11):3253. doi: 10.3390/molecules26113253. PMID: 34071375; PMCID: PMC8197926.
2. Vollmer DL, West VA, Lephart ED. Enhancing Skin Health: By Oral Administration of Natural Compounds and Minerals with Implications to the Dermal Microbiome. Int J Mol Sci. 2018 Oct 7;19(10):3059. doi: 10.3390/ijms19103059. PMID: 30301271; PMCID: PMC6213755.
3. Han G, Kim H, Kim DE, Ahn Y, Kim J, Jang YJ, Kim K, Yang Y, Kim SH. The Potential of Bovine Colostrum-Derived Exosomes to Repair Aged and Damaged Skin Cells. Pharmaceutics. 2022 Jan 27;14(2):307. doi: 10.3390/pharmaceutics14020307. PMID: 35214040; PMCID: PMC8877896.
4. Murata M, Satoh T, Wakabayashi H, Yamauchi K, Abe F, Nomura Y. Oral administration of bovine lactoferrin attenuates ultraviolet B-induced skin photodamage in hairless mice. J Dairy Sci. 2014 Feb;97(2):651-8. doi: 10.3168/jds.2013-7153. Epub 2013 Dec 18. PMID: 24359814.
5. Lolou V, Panayiotidis MI. Functional Role of Probiotics and Prebiotics on Skin Health and Disease. Fermentation. 2019; 5(2):41.https://doi.org/10.3390/fermentation5020041
6. Kim H, Jang Y, Kim EH, Jang H, Cho H, Han G, Song HK, Kim SH, Yang Y. Potential of Colostrum-Derived Exosomes for Promoting Hair Regeneration Through the Transition From Telogen to Anagen Phase. Front Cell Dev Biol. 2022 Mar 10;10:81520.
7. Zhong Y, Wang X, Zhao X, et al. Multifunctional Milk-Derived Small Extracellular Vesicles and Their Biomedical Applications. Pharmaceutics. 2023;15(5):1418. Published 2023 May 6. doi:10.3390/pharmaceutics15051418
8. Trüeb RM. Further Clinical Evidence for the Effect of IGF-1 on Hair Growth and [Alop-]. Skin Appendage Disord. 2018 Apr;4(2):90-95. doi: 10.1159/000479333.

Studies On Bovine Colostrum And Brain Health* (1-2)

1. Leszek J, Inglot AD, Janusz M, Lisowski J, Krukowska K, Georgiades JA. Colostrinin: a proline-rich polypeptide (PRP) complex isolated from ovine colostrum for treatment of [Alz-]. A double-blind, placebo-controlled study. Arch Immunol Ther Exp (Warsz). 1999;47(6):377-85. PMID: 10608295.
2. Leszek J, Inglot AD, Janusz M, Byczkiewicz F, Kiejna A, Georgiades J, Lisowski J. Colostrinin proline-rich polypeptide complex from ovine colostrum--a long-term study of its efficacy in [Alz-]. Med Sci Monit. 2002 Oct;8(10):PI93-6. PMID: 12388930.
Studies On Bovine Colostrum And The Urinary/Renal System* (1-2)
1. Conte AL, Longhi C, Conte MP, Costanzo AM, Paesano R, Santangeli S, Venditto F, Tripepi G, Naldi E, Pollio G, Cavallini V, Marrani M, Faltoni P, Valenti P, Rosa L. Effect of bovine lactoferrin on recurrent urinary tract [inf-]: in vitro and in vivo evidences. Biometals. 2023 Jun;36(3):491-507. doi: 10.1007/s10534-022-00409-1. Epub 2022 Jun 29. PMID: 35768747.
2. Park JK, Park HJ, Joo KJ. The Suppressive Effect of Bovine Colostrum Combined with Antibiotics on Renal [inflam-]. Korean J Urol. 2006 Oct;47(10):1111-1116. https://doi.org/10.4111/kju.2006.47.10.1111

Studies On Bovine Colostrum, Gut Health, And The Microbiome* (1-4)

1. Bagwe-Parab S, Yadav P, Kaur G, Tuli HS, Buttar HS. Therapeutic Applications of Human and Bovine Colostrum in the Treatment of Gastrointestinal [Dz] and Distinctive [CA] Types: The Current Evidence. Front Pharmacol. 2020 Sep 11;11:01100. doi: 10.3389/fphar.2020.01100. PMID: 33071773; PMCID: PMC7533576.
2. Koohi O, Shahriarirad R, Erfani A, Nekouei F, Seifbehzad S, Ebrahimi A, Tanideh N, Hosseinzadeh M, Nadimi E, Ashkani-Esfahani S. Evaluation of oral and topical bovine colostrum compared to mesalamine in the treatment of animal model of acetic acid-induced [UC]. Ann Gastroenterol. 2023 May-Jun;36(3):300-306. doi: 10.20524/aog.2023.0796. Epub 2023 Apr 8. PMID: 37144020; PMCID: PMC10152808.
3. Elsasser TH, Ma B, Ravel J, Kahl S, Gajer P, Cross A. Short-term feeding of defatted bovine colostrum mitigates [inflam-] in the gut via changes in metabolites and microbiota in a chicken animal model. Anim Microbiome. 2023 Jan 26;5(1):6. doi: 10.1186/s42523-023-00225-z. PMID: 36703224; PMCID: PMC9878500.
4. Zivkovic AM, Barile D. Bovine milk as a source of functional oligosaccharides for improving human health. Adv Nutr. 2011 May;2(3):284-9. doi: 10.3945/an.111.000455. Epub 2011 Apr 30. PMID: 22332060; PMCID: PMC3090169.